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RAGE binds preamyloid IAPP intermediates and mediates pancreatic beta cell proteotoxicity

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In this study, we have experimentally demonstrated that glutathione loss-triggered oxidative stress can induce neurodegeneration, and that neuroinflammation plays an important role in the process of oxidative stress-induced neurodegeneration

Additionally, mutations in the leptin receptor gene are associated with obesity in db/db mice and fa/fa rats

Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease Type of study: non-rct experimental Number of citations: 97 Year: 2014 Authors: H