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In a GSH-dependent manner, PRDX6 functions as a selenium acceptor and carrier, transferring selenium to selenophosphate synthetase 2 (SEPHS2) to support selenocysteine-tRNA synthesis required for GPX4 translation 106

Sensory nerve damage produces the symptoms most people associate with neuropathy: numbness, tingling, burning pain, pins-and-needles sensations, and hypersensitivity to touch

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