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The bisubstrate complex of NADP-dihydrofinasteride is a potent inhibitor with dissociation constant k i 1x 10 31 M that makes it as one of the extremely potent known non-covalently bound complexes

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To summarize, although very potent IRAP inhibitors have been discovered after systematic alterations starting from Ang IV none of the compounds are expected to reach the brain, at least not after oral administration

A microscopy-based screen identifies cellular kinases modulating mitochondrial translation