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Among the GLP-1 RAs, evidence of CV benefit is strongest for liraglutide, favorable for semaglutide, and less certain for exenatide

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Liraglutide Evidence level : FDA approved (Saxenda), extensive research SCALE trials : SCALE Obesity (Pi-Sunyer et al., 2015): 3,731 participants 56 weeks Result: 8.4% weight loss vs 2.8% placebo 33% achieved 10% weight loss Mechanism : Earlier-generation GLP-1 agonist, daily injection required