Chang C-W, Chen Y-S, Chou S-H, Han C-L, Chen Y-J, Yang C-C, et al
1 ) the microscopic presentation ( i.e., severe necrosis along the fistula wall, including a large necrotic area of superficial epithelium and a broad band of necrotic subcutaneous tissue and muscle after 3 days, fistulous channel walled with granulation tissue after 14 days) followed the described macroscopical healing and previous course of gastrocutaneous fistula-rats (11) (initially, in animals treated with BPC 157, the edema was less pronounced, the superficial epithelium surrounding the defect was practically intact, and the defect was closed by crust, and after 14 days, unlike in the controls, the treated animals showed poor granulation tissue formation and prominent regeneration of subcutaneous muscle fibers) (11)
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Consequently, cystine uptake coupled with glutamate excretion and glutathione synthesis are enhanced (Fig
