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Bioenergetic profiling The real-time OCR was measured using a Seahorse Mini HS XF instrument (Agilent)

Foretinib simultaneously inhibits cancer cells and lymphatic endothelial cells to reduce pancreatic tumor growth in vivo , and this data demonstrated for the first time that this inhibitor suppresses angiogenesis and lymphangiogenesis by blocking VEGFR-2/3 and TIE-2 signaling [77]