When to seek medical help See a doctor promptly if you have spreading redness or warmth around the site, discharge or a fever, numbness or weakness that does not settle, or any swelling of the face, lips or throat or difficulty breathing, which can signal a rare allergic reaction and is a medical emergency
This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity
Reported side effects in humans Clinical experience and user reports suggest that side effects, when they occur, are generally mild
Including iron-rich foods (red meat, beans, fortified cereals) and folate sources (green vegetables, pulses, fortified bread) can support red blood cell production
The compound's unique mechanism of action simultaneously preserving NAD+ availability and methylation capacity through selective NNMT inhibition offers researchers a powerful approach to investigating metabolic flexibility and cellular adaptation
