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The risk of bias was independently assessed by at least two investigators using of the adapted Downs and Black checklist, which is appropriate for both randomized and non-randomized studies ( Overview of study findings Study selection A total of 183 RCTs were inspected for eligibility, however, only 21 studies were selected, as shown in Figure 2

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Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a mendelian randomisation analysis