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This paradoxical effect might increase migraine frequency or intensity in some individuals

It is synthesized endogenously in humans

4 Circadian rhythms regulate post-IS BBB repair via immune system modulation 4.1 Circadian rhythms orchestrate immune cell-mediated BBB repair following IS After stroke, BBB dysfunction involves several inflammatory mechanisms, including increased matrix metalloproteinases (MMP-2/9), excessive ROS production, polarization of microglia toward pro-inflammatory states, and infiltration of peripheral leukocytes (8891)

doi: 10.1111/j.1749-6632.2000.tb06637.x

If your serum B12 is unexpectedly high despite supplementing at recommended doses, the first step is to investigate rather than immediately reduce your supplemental dose