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When cells are exposed to oxidative and/or electrophilic stress, KEAP1 thiol residues are directly modified, which inactivates the ubiquitin E3 ligase activity of KEAP1-CUL3 complex, leading to stabilization of NRF2

The Schistosoma mansoni host-interactive tegument forms from vesicle eruptions of a cyton network

Zhang W, Liu Z, Yang Z, Feng C, Zhou X, Tu C, Li Z (2021) MTHFR polymorphism is associated with severe methotrexate-induced toxicity in osteosarcoma treatment

Brancaccio, D

The researchers found that glutathione supplementation led to a significant reduction in disease activity, as measured by various clinical markers