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(What the Evidence Shows) Short answer: not on their own

According to the NIH criteria, a PCOS diagnosis necessitates the presence of both chronic anovulation and clinical or biochemical evidence of hyperandrogenism, after excluding other underlying causes

In delta and epsilon GSTs, His-38 is maintained in most cases as a polar or charged residue and His-50 is conserved as part of an NPQHTVPTL motif

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