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low doses use little

That means if you have no change in testosterone level or even estradiol level, free testosterone will go down

Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation

Stem Cells 26 , 25952601 (2008)

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