Acknowledgments This work was supported in part by National Natural Science Foundation of China (81571176 to XW, 91332114 and U1405222 to HX), the Thousand Young Talents Program of China, the Fundamental Research Funds for the Chinese Central Universities (20720150061 to XW), US National Institutes of Health grants (R01 AG038710, R01 AG021173, R01 NS046673, R01 AG030197, and R01 AG044420 to HX) and grants from the Alzheimers Association (to HX) and the Global Down Syndrome Foundation (DSADIIP-13-283543, to HX), BrightFocus Foundation (to HX), and Cure Alzheimers Fund (to HX)
of India, for Extra Mural Research Grant (File Number: 36/14/2020/TOX/BMS), and UGC for Startup Research Grant
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