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While hyperpigmentation can be caused by too much sun exposure, it may be the result of other factors, such as hormonal changes, skin injuries, inflammation, or age

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This process of accumulating DNA errors eventually leads to cell aging and dysfunction, or sometimes even to cancer

174,175 A also causes the formation and activation of the NLRP3 inflammasome within microglia, which releases ASC specks that bind rapidly to A in promoting A aggregates and the spread of A pathology

[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Kang EA, Han Y-M, An JM, Park YJ, Sikiric P, Kim DH, et al