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The bioavailability is lower, the absorption is more variable, and the daily dosing schedule replaces the once-weekly injection rhythm most users are familiar with

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Tissue loading may occur at even lower rates of administration

In a co-administered protocol the three components depopulate at different rates from a single bolus, which is one of the legitimate criticisms of any fixed-ratio blend: the researcher cannot independently titrate frequency for the shorter-half-life components without also re-dosing the longer-half-life one