Since vascular growth is not only up-regulated but also accompanied by significant changes in their architecture (i.e., abnormal vasculature, disorganization, etc.) and function [129,130], a tumor burdened with those vessels may eventually be resistant to various therapeutic methods, including systemic treatment in the form of chemotherapy or radiotherapy [131]
Aging (Albany NY) 8, 796809
Oli Genn-Bash: And I do think you start to clear out this junk, if you are engaging with your cellular system, with your [00:12:00] mitochondria, it is actually having this function of strengthening your oxidative, um, you know, the, the health of, of this kind of renewal of, um, anti-aging, of preventing certain disease
Davin8r September 10, 2024, 3:22am #8 Neo: Any sense of this increased baseline insulin levels, thats my worry with GLP-1 as CR mimetic that key longevity pathway (and IGF, etc) might actually go in the wrong direction with these Fasting insulin went down dose-dependently in the retatrutide phase 2 study, for instance (see Table S6): I havent looked at sema or tirz data specifically, but Id imagine its the same
Key Takeaways: GSH depletion in Type 2 Diabetes is driven by impaired synthesis, not just increased oxidative consumption
