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how they translate across routes is an open research question, not a solved one
Extended protocols may be appropriate for individuals with significant body composition goals, those who respond gradually to therapy, or patients seeking comprehensive metabolic optimization under close medical supervision
Megaloblastic anemia Diminished activity of methionine synthase in vitamin B 12 deficiency inhibits the regeneration of tetrahydrofolate (THF) and traps folate in a form that is not usable by the body ( Figure 3 ), resulting in symptoms of folate deficiency even in the presence of adequate folate
Those with confirmed deficiency may require parenteral (injectable) B12, as oral supplementation may be inadequate
Vitamin B12, B6, or folate and cognitive function in community-dwelling older adults: a systematic review and meta-analysis
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