Although the virion DNA was found to be mostly unmethylated in both tissue culture and patient serum 16,17 , DNA methylation of the intranuclear HBV genome has been associated with repression of gene transcription in cultures 24,25,26
ALT and AST reflect liver cell injury, ALP is another biliary-related enzyme, and bilirubin, albumin and INR give further insight into liver function
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