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Dosage should be adjusted flexibly according to the purpose of use, following the principle of gradual increment
not primarily appetite-driven (OUP Academic) Expected weight loss (this is where many people get misled) In major obesity trials: Semaglutide 2.4 mg weekly: ~14.9% mean weight loss at 68 weeks (STEP-1) (PubMed) Tirzepatide: ~15.0% to ~20.9% mean weight loss at 72 weeks , dose-dependent (SURMOUNT-1) (PubMed) AOD-9604s best-known human signal is kilograms, not double-digit percentages , and later studies did not sustain a strong obesity-drug profile
This represents the most common starting point in practical protocols and aligns with the midpoint of clinical dosing ranges adjusted for average body composition
Week 6-8: Clear fat loss By week 6-8, results are undeniable
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