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Sermorelins adult use is largely extrapolated from the pediatric approval and from observational studies, not from large randomized adult trials

Hadera et al., G93A mice (Tefera et al., 2016)

Crucially, besides inducing membrane depolarization through 7nAChR-gated Ca2+ conductance, there is growing evidence suggesting potential metabotropic activities of this ionotropic receptor [43]

The known side-effect categories, with approximate frequencies drawn from pediatric and adult data, include the following: Injection-site reactions (common, ~17%): Erythema, pruritus, and transient induration