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Maswada, H
When compared with the TAM-only group, the combination of JEKHT and TAM significantly downregulated Il-6 , Foxp3 /T regulatory cell (Treg) markers, and Tgf 1 that activate Treg (De Oliveira Andrade et al., 2019)
Sun (2021) a Chinese group working with APP/PS1 amyloid-pathology mice showed restoration of spatial learning with oral dosing (1.442.88 mg/kg, 3 months): neuron and synaptophysin counts rose, astrocyte and microglial activation fell, IL-1 and TNF- dropped and anti-inflammatory IL-10 increased
FIGURE 1 Glutathione S -transferase P1 is also involved in cell death regulation, interacting with apoptotic signaling pathways as for example c-Jun NH2-terminal kinase (JNK1), ERK1/ERK2, or tumor necrosis factor receptor-associated factor 2 (TRAF2