Interestingly, PNPLA3 I148M is not properly targeted by the UPS which likely promotes the disease-causing variant to accumulate on LDs (135) where it can disrupt protein-protein interactions critical for TAG hydrolysis (70, 75)
Our bodies however are only able to absorb 2g of vitamin B12 per meal, therefore additional supplementation may be beneficial
Patients with a severe needle phobia, tremors, poor eyesight, or cognitive impairment should have a partner, family member, or healthcare provider administer the injection instead
New clients receive a complimentary B12 injection for energy with any qualifying paid service
For patients with these conditions, a maintenance schedule of injections every one to three months is typical after getting their levels back up