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It was also reported the effect of flavokavain A in the extrinsic and intrinsic apoptosis pathways, since it can upregulate Bim, p23, DR5 and Bax and downregulate Ki67, survivin and XIAP in a dose-dependent manner [108,110,111]

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High resolution Structured Illumination Microscopy (SIM) of nuclei of senescent cells showed FOXO4 to reside within these PML bodies, adjacent to 53BP1-containing DNA-SCARS (Fig

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