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The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission

While cysteine readily oxidizes to form the disulfide cystine, cells contain less cystine than cysteine in the cytosol because the ubiquitous reducing agent, glutathione (which contains cysteine), effectively reverses the formation of cystine by a non-enzymatic reduction reaction

Our observations show increased consumption of ser/gly pathway metabolites in order to facilitate dTTP production, which may promote DNA repair and aid in recovery of NSCLC cells in response to irradiation, as NSCLC specific response