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Furthermore, in line with the beneficial effects of RAS blockers, researchers have also shown that the administration of empagliflozin, a SGLT2i, reduced the expression of IL-6, CCL2, and NF-B in the kidneys of diabetic Akita mice, as well as in cultured kidney tubular cells exposed to high glucose (152, 159)

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For instance, while cyclic peptides like CyRL-QN15 gain enzymatic resistance through rigid structures [84], tripeptides such as GHK maintain therapeutic potency while being more adaptable and versatile in formulation