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Half of the dose is administered in case of chronic diseases in animals

doi:10.1002/14651858.CD007411.pub4

Some peptides have oxidation-sensitive amino acids compared with more stable sequences, which means researchers may need to take additional precautions to keep them from degrading

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These include the bell-shaped dose-response curve, central effects after peripheral administration, a delayed and prolonged time course, and some penetration of the blood-brain barrier in essentially intact form