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In contrast, a reduced risk for breast cancer was observed in blind women, with potentially higher levels of melatonin throughout all day (although there is no evidence that blind people produce more melatonin than sighted people) However, the mechanisms by which melatonin exerts any of oncostatic effects remains to be established

So, we say, Wait a minute, how did these Wellderly get to age 90 or 89, and they have the same polygenic risk score? Well, you look at their lifestyle, and as you say, Harlan, its not deterministic. These people were relatively thin

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That is both their strength and their limitation