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Uniquely for nasal sprays, the stability testing program must include device performance tests spray content uniformity (SAC) and droplet size distribution (DSD) at stability time points alongside the standard formulation tests (assay, impurities, pH, appearance, viscosity)

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To overcome the short half-life and frequent subcutaneous administration of pramlintide, new amylin receptor agonists like cagrilintide have been developed

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This distribution pattern means injection location matters far less for Tb-500 than for localized peptides