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Following recovery from surgery we behaviorally tested these animals utilizing the Morris water maze task of spatial learning which has become one of the gold standard behavioral testing protocols for the evaluation of AD animal models [37]

Of note, similar to the situation in rats with inferior caval vein occlusion (Vukojevic et al., 2018), RTqPCR has the limitation of results only reflecting mRNA levels, which may not correlate with protein levels

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Another compelling area is muscle injury