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High levels of NAC (n-acetylcysteine) supplementation have been shown to temporarily reduce homocysteine levels.[ref] Excessive supplementation with B6, methylfolate, or betaine may cause homocysteine levels to trend to the low side in some people, but this isnt well documented in research studies

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Drug Metab Dispos 2020;48:326-36

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Brain Sci 15(3):242 Ahmadi A et al (2025) Anticancer effects of alpha-lipoic acid, a potent organosulfur compound by modulating matrix metalloproteinases and apoptotic markers in osteosarcoma MG-63 cells