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It also reduced the rate of DPC apoptosis (cell death) and increased the ratio of Bcl-2/Bax (pro-survival markers)

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Moreover, iCAFs showed interaction with surrounding T cells by secreting IL-6 and CXCL12, leading to establishment of a tumour-favourable microenvironment in gastric cancer [239]

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Known as the Black Death, bubonic plague killed millions of people in Europe during a series of outbreaks during the Middle Ages