In 2017, we reported that in certain Asian countries, women were getting glutathione injections (and probably still are) to alter their skin to a lighter, more desirable tone (though it's advised against because of limited safety data)
Its a crucial starting point
Cell Death Dis 17 , 644 (2026)
In trials comparing EPL with other treatments, EPL was significantly more effective than herbal medicine [24], vitamins plus inosine [21], and sibutramine [35] and significantly more effective than UDCA in one small double-blind trial [38], but less effective in another small trial in which no blinding was reported [27]
The National Cancer Institute warns that "too many enemas of any kind can cause changes in normal blood chemistry, chemicals that occur naturally in the body and keep the muscles, heart, and other organs working properly." Some experts specifically warn against using coffee as the stimulant in an enema, citing a lack of research on its potential effects