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10.1016/j.mehy.2015.11.016 13 BorosL

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Upon activation, autoreactive T lymphocytes differentiate into helper T (Th) cells, which secrete a variety of pro-inflammatory cytokines and chemokines that induce immune activation and inflammation ( T-reg: Regulatory T cells (Tregs) play a crucial role in cancer, autoimmune diseases, chronic inflammation, and infectious diseases by regulating self-tolerance and suppressing immune responses

[20] Patients should contact their GP or bariatric team promptly if they experience any of the following: New or worsening tingling, numbness, or weakness in the limbs Difficulty with balance, coordination, or memory Unexplained fatigue, breathlessness, or palpitations A sore or swollen tongue, or persistent mouth ulcers Any concern that they have missed supplementation for a prolonged period Symptoms that suggest anaemia, such as pallor or dizziness New or worsening neurological symptoms such as paraesthesia, gait disturbance, or cognitive change warrant same-day assessment