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& Beamer, W

Antioxidant enzymes such as SOD, GSH, CAT and HO1, whose upregulation augments the capacity to counteract ROS

Curr Protein Pept Sci

Further research is needed to investigate GSH dynamics longitudinally, validate these observations in independent cohorts, explore the therapeutic potential of antioxidant interventions, and confirm these findings in multicenter studies

PHH/PMH have some disadvantages including difficulty in culture, phenotype change at an early stage, metabolic enzymes easy inactivation, and individual differences between donors, which limit their practicability and reliability as an in vitro model