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doi: 10.1126/science.294.5545.1354 247 MazaheritehraniE.SalaA.OrsiC

Dosing, bioavailability, and safety in humans remain entirely speculative

Alameddine et al

Pickart L., Vasquez-Soltero J.M., Margolina A

Through metagenomic sequencing and in vitro coculture experiments of peripheral blood mononuclear cells (PBMCs), it was verified that butyrate can selectively expand peripheral blood Tregs in RA patients, inhibit the activation of conventional T cells (Tconvs), downregulate the production of anti-citrullinated peptide antibodies (ACPA), and reduce cartilage and bone tissue damage