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However, this axis balance is disrupted when cardiomyocytes prefer pyruvate-derived lactate production, accompanied by a concomitant decrease in lactate consumption at the onset of heart failure [136]

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FEBS Lett 448:301303 Schleisier K, Harwat M, Bohm V, Bitsch R (2002) Assessment of antioxidant activity by using different in vitro methods