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Mild digestive upset (including diarrhea or changes in bowel movements)
Relative change in body weight or food intake was calculated for each animal using the equation below following which results for all animals where computed to find the statistical mean
By doing so, the recorded events are specifically induced by the substance, rather than being a result of overall cytotoxicity and cell death ( When selecting the exposure concentration, it is also important to consider other physiological factors, such as the route of administration and distribution, and pharmacological factors, such as Cmax, to prevent the use of unrealistic exposure scenarios (Supplementary Table S1 summarizes the concentration ranges analyzed in the reviewed results
Bolajoko EB
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