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From the present review, it is evident that small peptides exert towards oral cells and tissues an antitumor activity through apoptosis or selective necrosis of cell lines specifically associated with oral squamous cell carcinoma, an antimicrobial function by maintaining the balance of the oral microbiome, an immunomodulatory function through up and down-regulation of important genes involved in immunoregulatory gene cascades, and finally a cell differentiation function towards major stem cells in the oral cavity, even in absence of growth factors [21, 27,28,29,30,31, 34, 35]

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This antioxidant defense is critical for breaking the vicious cycle of oxidative stress seen in chronic illness

Across different organs, protein-bound lysine is methylated to form -N-trimethyllysine in a reaction catalyzed by specific lysine methyltransferases that use S-adenosyl-methionine (derived from methionine) as a methyl donor