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However, in patients with CLF, an improvement in recurrent bouts of HE was shown, while the treatment was well tolerated and was shown to be superior to placebo [71]

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Mechanistic studies suggest that organ-specific delivery patterns and the in vivo fate of ZP-LNPs are largely governed by pKa values and the composition of the protein corona

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45 Moreover, a meta-analysis assessing the effect of N-acetylcysteine (NAC) confirmed its positive impact on key inflammatory parameters (eg, CRP, D-dimers) and improvement in the PaO2/FiO2 ratio, suggesting clinical benefits for COVID-19 prognosis