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Materials and methods Reagents and materials Oxidized glutathione (GSH) 2 , homocystine (Hcy) 2 , cystine (Cys) 2 , TCEP, benzyl bromide, 2-chloropyridine, L-lysine, N-acetylcysteine (NAC), 2-mercaptoethanesulfonic acid (MESNA), N-(2-mercaptopropionyl)-glycine (MPG), [2 S]-1-[3-mercapto-2-methylpropionyl]-L-proline (Captopril), and lipoic acid (LA), and ethylenediaminetetraacetic acid (EDTA) were received from the Sigma Aldrich Company (St

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It also stimulates the release of pro-inflammatory cytokines, such as IL-6 and TNF-, and may synergize with circulating LPS to exacerbate systemic inflammation

Rtn1-c mediates cerebral ischemia/reperfusion injury via er stress and mitochondria-associated apoptosis pathways