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(4) We decreased the leakage rate of cytosolic cysteine from the cytosol to the blood from 1 to 0.25 h

Tian, G., Sawashita, J., Kubo, H., Hashimoto, S., Suzuki, N., Yoshimura, H., Tsuruoka, M., Wang, Y., Liu, Y., Luo, H., Xu, Z., Mori, M., Kitano, M., Hosoe, K., Takeda, T., & Higuchi, K

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This creates a dangerous bottleneck where highly toxic Phase I intermediates accumulate in the liver, leading to systemic toxicity, severe hepatic inflammation, and a cascading failure of the body's natural waste-removal systems