No trial reported on clinical signs and symptoms of vitamin B 12 deficiency, health-related quality of life, or acceptability of the treatment scheme Orally taken vitamin B 12 showed lower treatment-associated costs than intramuscular vitamin B 12 in one trial
The supplement market offers B12 products containing 1,0005,000 micrograms per dose, vastly exceeding the recommended nutrient intake of 1.5 micrograms daily for adults
No validated reconstitution ratio exists
Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome
doi: 10.1016/j.expneurol.2008.04.039