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Reporting summary Further information on research design is available in the Nature Research Reporting Summary linked to this Article

Traditional medicine has obvious advantages for chronic diseases, therefore, more clinical trials should be performed to understand the regulation process of MO

Maintaining adequate levels of B vitamins is essential to support energy metabolism throughout the ageing process, helping seniors to stay active and engaged

For example, glycine receptors have been identified on the outer surface of several different types of immune cells (71, 72)

or the acquisition, analysis or interpretation of data