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The CagriSema metabolic preservation mechanism, specifically the maintenance of mitochondrial function in skeletal muscle during weight loss, could theoretically slow the rate of weight regain by preventing some of the metabolic adaptation that makes regain almost inevitable

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154-158 At follow-up durations ranging from six weeks to 12 months, efficacy rates ranged from 61% to 70% with some studies also reporting significant improvements in voiding parameters and validated questionnaires

it is descriptive of what the literature and protocol structure suggest, not a promise of results