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It is proposed that the non-ubiquitinated NRF2 would remain bound to the KEAP1-Cul3 complex and therefore prevent the newly translated NRF2 from inhibition by the E3-ubiquitin complex, thereby promoting NRF2 accumulation in the nucleus [17]
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The broader preclinical record, reviewed exhaustively by Graf and Kastin [4, 5], includes sleep-architecture effects in rats and mice, and predominantly REM-related effects in cats a species-specificity that the delta sleep-inducing name does not capture
Some researchers have used subcutaneous injection of scopolamine combined with a dry environment to establish DED mouse models, and immortalized human HCEC-2 cells were cultured under hypertonic conditions to establish hypertonic cell injury models and measure the levels of intracellular Fe 2+ , cellular ROS, and lipid peroxidation
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