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In T cells, the activity of the C3GCRKL complex is negatively regulated by the E3 ubiquitin ligase CBLB

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Overall, the decrease of total macrophage population and M2 subphenotype excluded the macrophages polarization from the pathway enrichment after CD5/ LNP-FAPCAR 2.2 treatment

Consequently its metabolites such as carbon monoxide (CO), biliverdin (BV) and bilirubin (BR) could become parts of a therapeutic strategy for treatment of various inflammatory illnesses Key words Biliverdin, bilirubin, antioxidant, anti-inflammatory, cytoprotection