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The net result of this mechanism of action is that overexpression of melanin is attenuated which means less hydrogen peroxide production and localized hyperpigmentation

In PTZs, substitutions at the C-10 position, such as alkyl or aryl groups, reduce activity, whereas modifications at the C-2 position significantly enhance potency, such as featuring a 2-phenyl-methyl piperazine at C-2, which demonstrated remarkable activity with an EC50 of 0.5 nM in erastin-induced ferroptosis in HT-1080 cells (Yang et al., 2021)

Article contents Abstract Molecular basis of the chemoprotective effects of isothiocyanates Induction of antioxidant and detoxifying enzymes by isothiocyanates Selenium and cancer prevention heterogeneity: metabolism and antioxidant functions Dietary modulation of epigenetic modifications and cancer Epigenetic modulation of gene expression by dietary isothiocyanates Role of selenium in DNA methylation changes Conclusion References Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention Published online by Cambridge University Press: 06 March 2012 Abstract Molecular basis of the chemoprotective effects of isothiocyanates Induction of antioxidant and detoxifying enzymes by isothiocyanates Selenium and cancer prevention heterogeneity: metabolism and antioxidant functions Dietary modulation of epigenetic modifications and cancer Epigenetic modulation of gene expression by dietary isothiocyanates Role of selenium in DNA methylation changes Conclusion References Abstract There is evidence from epidemiological studies suggesting that increased consumption of cruciferous vegetables may protect against specific cancers more effectively than total fruit and vegetable intake