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Nitric oxide (NO) is used to initiate defensive protection in mammals and accumulates in the brain [100]
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In the nucleus, ACSS2 interacts with TFEB and facilitates site-specific H3K9 acetylation at the promoters of autophagy and lysosomal genes, including LAMP1, ATG5 , and GABARAPL1 , thus increasing transcription and promoting cell survival under stress