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Suspected neurological involvement due to B12 deficiency warrants urgent initiation of treatment and may require specialist referral

For weight management and metabolic conditioning: 100150 mg daily, in 12 divided doses

In addition, low IGF-1 subjects in a study were found to possess up-regulated fatty acid metabolism along with down-regulated GLUT-1 gene (in charge of glucose uptake in erythrocytes, brain endothelial cells, eye, peripheral nerve and also responsible for materno-placental glucose transfer) [210]

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No clinical trials demonstrate additional weight loss benefit from adding lipotropic injections to tirzepatide