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Both agents have poor solubility, which may limit their use in clinical practice ( There are many other potential selective NOX inhibitors (e.g., fulvene-5, triphenylmethane derivatives, celastrol, some synthetic diarylheptanoids, grindelic acid, dietary flavonoids, shionogi I and II, and perhexiline)

Causes and Risk Factors Dehydration is an important risk factor for all types of kidney stones